Studies on the Pyridine Derivatives. V

Studies on Normal and Leukemic Leukocytes. v. Pyridine Nucleotide Transhydrogenases.

The function of these enzymes in vivo is not yet entirely clear, but the TD transhydrogenase may link TPNH to the mitochondrial electron transport system that oxidizes DPNH via molecular oxygen. The DD enzyme, alternatively, may function in the equilibration of free and mitochondrial-bound DPN (3). Hormonal influence on transhydrogenase reactions has been noted by Villee (5), who described the ...

Studies on pyridine nucleotide biosynthesis.

Until recently it had been generally accepted that the formation of diphosphopyridine nucleotide in biological systems starts from nicotinamide, with nicotinamide riboside and nicotinamide mononucleotide as intermediates (Singer & Kearney, 1954). Much of the earlier work on whether nicotinic acid or nicotinamide is the more efficient precursor of diphosphopyridine nucleotide has been controvers...

Molecular docking studies on pyridine derivatives of glitazones as PPARy agonists

FlexX software has been employed to perform molecular docking analysis on a series of glitazones in the act ive site of PPARy. FlexX scores and interaction energies of glitazones have been compared with those of the correspond ing pyridine analogs. The results point out that the binding affinities do not significantly change due to the benzene versus pyridine substitution in the central ring of...

Studies on nicotinamide derivatives.

Synthesis and Molecular Docking studies of Some Tetrahydroimidazo[1,2-a] pyridine Derivatives as Potent α-Glucosidase Inhibitors

KAl(SO4)2.12H2O is found to efficiently and heterogeneously catalyze the one-pot three-component reaction of 2-(nitromethylene)imidazolidine, malononitrile and aldehydes under mild conditions to afford the corresponding tetrahydroimidazo[1,2-a]pyridine in good yields and short reaction times. Docking  study  of  some  compounds  in  the  active  site  of  α-glucosidase demonstrated  that  these...